期刊簡介預(yù)計審稿時間： 約2.1個月

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following:

* Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.

* Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.

*Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.

* Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.

*Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.

* Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.

* Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.

* Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

《藥物化學(xué)雜志》發(fā)表的研究有助于理解分子結(jié)構(gòu)與生物活性或作用方式之間的關(guān)系。

一些適當?shù)奶囟I(lǐng)域包括：

* 設(shè)計、合成和生物學(xué)評估用作藥理學(xué)工具的新型生物活性化合物、診斷劑或標記配體。

* 對已報道的系列進行分子修飾，從而顯著提高對其結(jié)構(gòu)-活性關(guān)系 (SAR) 的理解?，F(xiàn)有系列的常規(guī)擴展，如果不采用新的化學(xué)或生物學(xué)方法，或者沒有顯著增加對系列 SAR 的基本理解，通常不會被接受出版。

*相關(guān)配體和靶標的結(jié)構(gòu)生物學(xué)研究（X 射線、NMR 等），旨在研究生物活性化合物作用中的分子識別過程。

*大分子靶標的分子生物學(xué)研究（例如，定點誘變），可提高對分子識別的理解。

*計算研究，為當前普遍感興趣的化合物系列的 SAR 提供新的見解，或分析其他可用數(shù)據(jù)，從而促進藥物化學(xué)知識。

*具有顯著價值的實質(zhì)上新穎的計算化學(xué)方法，可用于生物活性分子的鑒定、優(yōu)化或靶標相互作用分析。

*分子結(jié)構(gòu)對生物活性分子的分布、藥代動力學(xué)和代謝轉(zhuǎn)化的影響化合物。這可能包括新型前體藥物的設(shè)計、合成和評估。

* 廣泛應(yīng)用于藥物化學(xué)的新方法，但前提是這些方法已經(jīng)在相關(guān)分子上進行了測試。

《Journal Of Medicinal Chemistry》(藥物化學(xué)雜志)編輯部通訊方式為AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036。如果您需要協(xié)助投稿或潤稿服務(wù)，您可以咨詢我們的客服老師。我們專注于期刊投稿服務(wù)十年，熟悉發(fā)表政策，可為您提供一對一投稿指導(dǎo)，避免您在投稿時頻繁碰壁，節(jié)省您的寶貴時間，有效提升發(fā)表機率，確保SCI檢索（檢索不了全額退款）。我們視信譽為生命，多方面確保文章安全保密，在任何情況下都不會泄露您的個人信息或稿件內(nèi)容。